Diagram of Salesforce Health Cloud interoperability. Health Cloud with HL7 FHIR connects via MuleSoft Direct for Health Cloud and Data Cloud for Health to external systems including EHRs, payer systems, health networks, emerging data sources, and data lakes/warehouses.

Advance Interoperability in Healthcare

At Salesforce, we believe in collaboration. Our innovations, open ecosystem, and partner integrations have established us as a leader in interoperability. We understand the importance of end-to-end connection and caring for patients across the entire health journey. That’s why we're dedicated to helping healthcare companies share data with ease.

Healthcare organizations worldwide trust Salesforce for interoperability.

MuleSoft Direct for Health Cloud

MuleSoft Direct for Health Cloud offers comprehensive integration solutions tailored to fit the healthcare industry's needs. It is a set of prebuilt, ready-to-use integrations that work with leading electronic health records (EHRs), payer networks, and health information exchanges. These integrations work natively within Salesforce, connecting outbound calls to healthcare systems for real-time workflows and data ingestion.

These integrations allow you to connect Health Cloud to all certified EHRs and receive structured patient data in real time with no storage in Salesforce. They also allow you to pull data in bulk from EHRs into Data Cloud. The connected data helps you optimize population health management, risk scoring, and cohort analysis. Additionally, you can extract data from C-CDA-aligned documents into Data Cloud.

Salesforce Health Cloud interface showing Agentforce retrieving recent medication records for Charles Smith. The summary lists paracetamol dosage, maximum dose, and usage notes for pain management.

These FHIR-based integrations allow for immediate access to essential payer information, such as member data, coverage, and explanations of benefits (EOBs). Users can also access provider directories, manage prior authorizations, and ingest EOBs into Data Cloud.

Salesforce Health Cloud with Agentforce verifying Charles Smith’s insurance coverage. Benefits details include network type, amount, co-pay, and deductible. A badge shows insurance coverage as verified

These integrations allow users to acccess patient demographics across the TEFCA (Trusted Exchange Framework and Common Agreement) network through our partnership with KNo2 as well as retrieve and extract data from semi-structured clinical documents aligned with C-CDA format into Data Cloud.

Diagram of KNo2 interoperability with Salesforce Health Cloud and organization EHR. Data flows through MuleSoft to connect wearables, consumer apps, provider EHRs, and health information exchanges (HIE)
Salesforce Health Cloud interface showing Agentforce retrieving recent medication records for Charles Smith. The summary lists paracetamol dosage, maximum dose, and usage notes for pain management.
Salesforce Health Cloud with Agentforce verifying Charles Smith’s insurance coverage. Benefits details include network type, amount, co-pay, and deductible. A badge shows insurance coverage as verified
Diagram of KNo2 interoperability with Salesforce Health Cloud and organization EHR. Data flows through MuleSoft to connect wearables, consumer apps, provider EHRs, and health information exchanges (HIE)

FHIR APIs on Health Cloud

Our robust, inbound FHIR API library allows external systems to read, write, and update data directly into Health Cloud data models, all using open standards.

SMART on FHIR is an open-source, standards-based API that provides secure access to EHRs. This allows healthcare apps to seamlessly integrate with Health Cloud.

Diagram showing SMART on HL7 FHIR integration with Salesforce Health Cloud. External apps connect through HL7 FHIR APIs to enable secure data exchange with Health Cloud.

Send and receive patient-reported outcomes, social determinants of health (SDOH) assessments, and all types of healthcare forms using FHIR-based questionnaires.

Salesforce Health Cloud diabetes assessment form. Interface shows configurable general questions alongside a detailed assessment questionnaire about blood sugar monitoring and recent episodes

Configure external systems and middleware to trigger FHIR requests to send data to Health Cloud.

Diagram of MuleSoft integration between an EHR system and Salesforce Health Cloud. Patient data flows from the EHR through MuleSoft, is upserted into Health Cloud, and responses return to the EHR
Diagram showing SMART on HL7 FHIR integration with Salesforce Health Cloud. External apps connect through HL7 FHIR APIs to enable secure data exchange with Health Cloud.
Salesforce Health Cloud diabetes assessment form. Interface shows configurable general questions alongside a detailed assessment questionnaire about blood sugar monitoring and recent episodes
Diagram of MuleSoft integration between an EHR system and Salesforce Health Cloud. Patient data flows from the EHR through MuleSoft, is upserted into Health Cloud, and responses return to the EHR

Data Cloud for Healthcare Interoperability

See healthcare and life sciences use cases for Data Cloud.

Gain a holistic view of every patient's health with clinical and nonclinical factors. This includes their demographic, claims, medical, social, and behavioral history in one real-time profile. Use these insights to proactively improve patient outcomes, increase shared savings, and strengthen member and population health.

Diagram showing SMART on HL7 FHIR integration with Salesforce Health Cloud. External apps connect through HL7 FHIR APIs to enable secure data exchange with Health Cloud.

Seamlessly collaborate through every phase of the clinical trial process on a compliant platform. Identify potential risks for patients, candidates, or studies. Generate targeted outreach to specific segments and engage with them based on their preferences. Securely connect and activate data from multiple sources — external and internal clinical sites, claims, and commercial systems. Use this data to create real-time profiles of patients, healthcare professionals (HCPs), and clinical sites

Salesforce Clinical Excellence dashboard showing a clinical study workflow. Timeline includes protocol approval, site/vendor identification, and participant screening, with study details and investigator info

Engage HCPs across every channel with the right information at the right time. This personalized approach helps increase prescribing likelihood. Build stronger relationships with a complete view of each HCP, including their specialties, subspecialties, payer relationships, panel status, education, awards, and board certifications. Help sales reps prioritize their activities with intelligent Next Best Action prompts that recommend the best content and conversations for each situation.

A doctor receives an emailed survey from a healthcare company

Speed up the prior authorization process with automation at every step. Analyze historical claims data to power actionable insights and AI.

An HCP receives a task from Salesforce Care Connect to complete an assessment
Diagram showing SMART on HL7 FHIR integration with Salesforce Health Cloud. External apps connect through HL7 FHIR APIs to enable secure data exchange with Health Cloud.
Salesforce Clinical Excellence dashboard showing a clinical study workflow. Timeline includes protocol approval, site/vendor identification, and participant screening, with study details and investigator info
A doctor receives an emailed survey from a healthcare company
An HCP receives a task from Salesforce Care Connect to complete an assessment
Diagram showing Salesforce Health Cloud interoperability with EHRs, Epic, and Cerner systems. MuleSoft integrates HL7 V2+ and HL7 FHIR standards to exchange resources like patient, practitioner, encounter, condition, observation, and procedures with digital front door apps and data science platforms

Health and Life Sciences Accelerators

Salesforce accelerators speed up time to value across healthcare. If you choose to build interoperability solutions yourself, we offer comprehensive support — guides, tools, videos, API specs, and code samples — to help you build and scale quickly and efficiently.

Diagram showing Salesforce Health Cloud interoperability with EHRs, Epic, and Cerner systems. MuleSoft integrates HL7 V2+ and HL7 FHIR standards to exchange resources like patient, practitioner, encounter, condition, observation, and procedures with digital front door apps and data science platforms

Agentforce's Role in Interoperability

Agentforce plays a crucial role in interoperability by ensuring trust, security, and compliance in data exchange. It gathers data from various systems through APIs and uses it as essential fuel for AI-driven insights. Agentforce enables seamless communication between agents and across enterprise systems, streamlining complex workflows and enhancing connectivity.

Proven value with Salesforce.

28 %
reduction in time spent on manual tasks
30 %
increase in patient volume/patient acquisition
31 %
increase in physician referral volume
27 %
increase in member satisfaction for payers

Our partners are here to guide you every step of the way — from research to remedy.

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